Anomia: Party Edition adds 6 new decks to the Anomia card game family. Each deck is a word game in which players sequentially place a card face-up in front of them in a stack. As each card is revealed, players look for matching symbols between their card and any other card. If a match occurs, the two matching players face-off and must quickly give an example of something within the category (eg. breakfast food, lake, reptile) listed on the opposing player's card. The first person to finish saying a correct answer wins the face-off and takes the opponent's card into a face down "winnings" pile. Since cards are played on top of each other, the player who lost the face-off reveals an earlier card on their stack and may immediately match another player's card causing a cascade of face-offs.
In addition there are wildcards which allow different symbols to match until it is overwritten by another wildcard which may then trigger a whole new set of face-offs. Play continues until the deck is exhausted and whoever has the most cards in their "winnings pile" is the winner.